Diffuse alopecia is seen in the scalp of this patient with systemic lupus erythematosus. Diffuse hair loss is most common in systemic lupus, although patchy baldness can appear. The hair usually regrows slowly when the disease becomes inactive. Not seen in this slide are the short hairs with a cut-off appearance, found in the frontal scalp area, that are typical of alopecia. Localized lesions of discoid lupus may damage hair follicles and result in permanent alopecia.